Eagle Lab


Curriculum vitae


Department of Neuroscience

The University of Texas at Dallas



Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin


Journal article


R. Mongrédien, Augusto Anésio, G.J.D. Fernandes, A. Eagle, Steeve Maldera, Cuong Pham, Adèle Vilette, P. Bianchi, Clara Franco, F. Louis, C. Gruszczynski, Catalina Betancur, A. M. Erdozain, A. J. Robison, A. Boucard, Dongdong Li, F. Cruz, S. Gautron, N. Heck, V. Vialou
bioRxiv, 2023

Semantic Scholar DOI
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APA   Click to copy
Mongrédien, R., Anésio, A., Fernandes, G. J. D., Eagle, A., Maldera, S., Pham, C., … Vialou, V. (2023). Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin. BioRxiv.


Chicago/Turabian   Click to copy
Mongrédien, R., Augusto Anésio, G.J.D. Fernandes, A. Eagle, Steeve Maldera, Cuong Pham, Adèle Vilette, et al. “Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward through the Matricellular Protein Hevin.” bioRxiv (2023).


MLA   Click to copy
Mongrédien, R., et al. “Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward through the Matricellular Protein Hevin.” BioRxiv, 2023.


BibTeX   Click to copy

@article{r2023a,
  title = {Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin},
  year = {2023},
  journal = {bioRxiv},
  author = {Mongrédien, R. and Anésio, Augusto and Fernandes, G.J.D. and Eagle, A. and Maldera, Steeve and Pham, Cuong and Vilette, Adèle and Bianchi, P. and Franco, Clara and Louis, F. and Gruszczynski, C. and Betancur, Catalina and Erdozain, A. M. and Robison, A. J. and Boucard, A. and Li, Dongdong and Cruz, F. and Gautron, S. and Heck, N. and Vialou, V.}
}

Abstract

Drug addiction involves profound modifications of neuronal plasticity in the nucleus accumbens, which may engage various cell types. Here, we report prominent effects of cocaine on calcium signals in astrocytes characterized by in vivo fiber photometry. Astrocyte calcium signals in the nucleus accumbens are sufficient and necessary for the acquisition of cocaine seeking behavior. We identify the astrocyte-secreted matricellular protein hevin as an effector of the action of cocaine and calcium signals on reward and neuronal plasticity.


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