Journal article
J. Siemian, Miguel Arenivar, Sarah Sarsfield, C. Borja, Lydia J. Erbaugh, A. Eagle, A. J. Robison, G. Leinninger, Yeka Aponte
eLife, 2021
eLife, 2021
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APA
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Siemian, J., Arenivar, M., Sarsfield, S., Borja, C., Erbaugh, L. J., Eagle, A., … Aponte, Y. (2021). An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice. ELife.
Chicago/Turabian
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Siemian, J., Miguel Arenivar, Sarah Sarsfield, C. Borja, Lydia J. Erbaugh, A. Eagle, A. J. Robison, G. Leinninger, and Yeka Aponte. “An Excitatory Lateral Hypothalamic Circuit Orchestrating Pain Behaviors in Mice.” eLife (2021).
MLA
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Siemian, J., et al. “An Excitatory Lateral Hypothalamic Circuit Orchestrating Pain Behaviors in Mice.” ELife, 2021.
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@article{j2021a,
title = {An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice},
year = {2021},
journal = {eLife},
author = {Siemian, J. and Arenivar, Miguel and Sarsfield, Sarah and Borja, C. and Erbaugh, Lydia J. and Eagle, A. and Robison, A. J. and Leinninger, G. and Aponte, Yeka}
}
Abstract
Understanding how neuronal circuits control nociceptive processing will advance the search for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic parvalbumin-positive (LHPV) glutamatergic neurons respond to acute thermal stimuli and a persistent inflammatory irritant. Moreover, their chemogenetic modulation alters both pain-related behavioral adaptations and the unpleasantness of a noxious stimulus. In two models of persistent pain, optogenetic activation of LHPV neurons or their ventrolateral periaqueductal gray area (vlPAG) axonal projections attenuates nociception, and neuroanatomical tracing reveals that LHPV neurons preferentially target glutamatergic over GABAergic neurons in the vlPAG. By contrast, LHPV projections to the lateral habenula regulate aversion but not nociception. Finally, we find that LHPV activation evokes additive to synergistic antinociceptive interactions with morphine and restores morphine antinociception following the development of morphine tolerance. Our findings identify LHPV neurons as a lateral hypothalamic cell type involved in nociception and demonstrate their potential as a target for analgesia.